Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
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چکیده
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Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin
One week of treatment with EGF and gastrin (EGF/G) was shown to restore normoglycemia and to induce islet regeneration in mice treated with the diabetogenic agent alloxan. The mechanisms underlying this regeneration are not fully understood. We performed genetic lineage tracing experiments to evaluate the contribution of beta cell neogenesis in this model. One day after alloxan administration, ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2004
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-003-1287-1